Miller Fisher Syndrome

Synonym(s) - Fisher Syndrome - Guillain Barre Syndrome, Miller Fisher Variant - Ophthalmoplegia, Ataxia and Areflexia Syndrome - Miller Fisher Variant of Guillain Barre Syndrome - Syndrome, Fisher

Definition: A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)

Broader term(s)

• Nervous System Diseases
• Autoimmune Diseases of the Nervous System
• Polyradiculoneuropathy
• Guillain-Barre Syndrome
• Miller Fisher Syndrome